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Leflunomide, sold under the brand name Arava among others, is an immunosuppressive disease-modifying antirheumatic drug , [8] used in active moderate-to-severe rheumatoid arthritis and psoriatic arthritis. It is a pyrimidine synthesis inhibitor that works by inhibiting dihydroorotate dehydrogenase. [9] Bottle of Leflunomide (Arava) and tablet
Rarer causes which usually behave differently but may cause joint pains: [88] Sarcoidosis, amyloidosis, and Whipple's disease can also resemble RA. Hemochromatosis may cause hand joint arthritis. Acute rheumatic fever can be differentiated by a migratory pattern of joint involvement and evidence of antecedent streptococcal infection.
A dorsal view of the hand, revealed swelling of the finger joints, indicative of an underlying inflammatory process at the proximal interphalangeal joints Common antiarthritic drug classes include the following: disease-modifying antirheumatic drugs , biologic response modifiers , analgesics , non-steroidal anti-inflammatory drugs , and ...
It causes round skin lesions which can be more prone to skin cancer. These lesions can affect the scalp as well as the rest of the body. Lupus-related hair loss can be caused by:
An imbalance can cause fluid overload in the spaces between cells or tissues, which can lead to edema, ... Swelling in legs, arms, feet or hands. Distended abdomen. Puffy, dough-like skin.
Swollen digits are a common sign, and on occasion, the complete hand swells. [15] [16] Acrosclerosis, also known as sclerodactyly, can develop with or without proximal scleroderma and is usually a later symptom of the condition. [10] Rashes are found in 50-60% of patients. [10]
Allergic reactions are a relatively common cause of throat swelling in general, but sometimes the uvula can be affected alone. “This is known as uvular angioedema,” says Dr. Morrison.
Individuals affected by RS3PE typically have repeated episodes of inflammation of the lining of their synovial joints and swelling of the end portion of the limbs. [8] The arms and hands are more commonly affected than the legs and feet. [8] Both sides are usually involved though RS3PE can affect only one side in certain cases. [8]