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Paroxetine was the first antidepressant approved in the United States for the treatment of panic disorder. [27] [page needed] Several studies have concluded that paroxetine is superior to placebo in the treatment of panic disorder. [25] [28] Paroxetine has demonstrated efficacy for the treatment of social anxiety disorder in adults and children.
Over two million prescriptions for paroxetine were written for children or adolescents in the US in 2002. [29]Funded by SmithKline Beecham, the acute phase of study 329 was an eight-week, double-blind, randomized clinical trial conducted in 12 university or hospital psychiatric departments in the United States and Canada between 1994 and 1997.
Drugs known as antidepressants are often the first choice prescribed by healthcare professionals. ... Paroxetine also has a higher risk of drug interactions and may impact sleep quality more than ...
This is a complete list of clinically approved prescription antidepressants throughout the world, as well as clinically approved prescription drugs used to augment antidepressants or mood stabilizers, by pharmacological and/or structural classification. Chemical/generic names are listed first, with brand names in parentheses.
Paroxetine CR was superior to placebo on the primary outcome measure. In a 10-week randomized controlled, double-blind trial escitalopram was more effective than placebo. [33] Fluvoxamine, another SSRI, has shown positive results. [34] However, evidence for their effectiveness and acceptability is unclear. [35]
Paroxetine is the most potent SSRI drug available, but it is less selective for SERT than fluvoxamine and sertraline. [43] Paroxetine also has weak NET inhibition which could contribute to its efficacy in depression, especially at higher doses.
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Serotonin. A serotonin reuptake inhibitor (SRI) is a type of drug which acts as a reuptake inhibitor of the neurotransmitter serotonin (5-hydroxytryptamine, or 5-HT) by blocking the action of the serotonin transporter (SERT).
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