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While dendrobine's effects on humans have not been studied extensively, studies of its pharmacological effects on various small animals were conducted in 1935 by Chen and Chen. [2] It was concluded that dendrobine exhibited a weak analgesic effect when administered to mice (5–15 mg/kg), and an antipyretic effect when administered to rabbits ...
Cannabis consumption in pregnancy is an important public health issue. Research has found possible or likely associations between cannabis use and a risk of adverse outcomes in respect of cognitive development, mental health, physical health, and lactation. [1] Cannabis is the most commonly used controlled substance among pregnant women. [2]
As the known health risks for marijuana grow, pregnant women should feel free to discuss any cannabis use with their health care provider without fear of reprisal, experts say.
Cannabis use during pregnancy should be avoided. [80] There is no known safe dose of cannabis while pregnant and use of cannabis may lead to birth defects, pre-term birth, or low birth weight. [80] Tetrahydrocannabinol (THC), an active ingredient in cannabis, can both cross the placenta and accumulates in high concentrations in breast milk. [81]
CBN was the first cannabis compound to be isolated from cannabis extract in the late 1800s. Its structure and chemical synthesis were achieved by 1940 [34], followed by some of the first pre-clinical research studies to determine the effects of individual cannabis-derived compounds in vivo. [35]
[19] [20] [26] As the legal landscape and understanding about the differences in medical cannabinoids unfolds, experts are working to distinguish "medical cannabis" (with varying degrees of psychotropic effects and deficits in executive function) from "medical CBD therapies", which would commonly present as having a reduced or non-psychoactive ...
Women who used marijuana during pregnancy were more likely to give birth to babies who were preterm, had lower birth weight and had a higher rate of birth defects, according to a major study of 1. ...
A 2005 meta analysis concluded that adolescent use of cannabis increases the risk of psychosis, and that the risk is dose-related. [48] A 2004 literature review on the subject concluded that cannabis use is associated with a two-fold increase in the risk of psychosis, but that cannabis use is "neither necessary nor sufficient" to cause ...