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A topical anesthetic is a local anesthetic that is used to numb the surface of a body part. They can be used to numb any area of the skin as well as the front of the eyeball, the inside of the nose, ear or throat, the anus and the genital area. [1]
Cinchocaine (INN/BAN) or dibucaine is an amide local anesthetic. Among the most potent and toxic of the long-acting local anesthetics, current use of cinchocaine is generally restricted to spinal and topical anesthesia. [1] [2] It is sold under the brand names Cincain, Nupercainal, Nupercaine and Sovcaine.
Pramocaine (INN and BAN, also known as pramoxine or pramoxine HCl) is a topical anesthetic discovered at Abbott Laboratories in 1953 [1] and used as an antipruritic.During research and development, pramocaine hydrochloride stood out among a series of alkoxy aryl alkamine ethers as an especially good topical local anesthetic agent. [1]
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Many local anesthetics fall into two general chemical classes, amino esters (top) and amino amides (bottom). A local anesthetic (LA) is a medication that causes absence of all sensation (including pain) in a specific body part without loss of consciousness, [1] providing local anesthesia, as opposed to a general anesthetic, which eliminates all sensation in the entire body and causes ...
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Dibucaine, also known as cinchocaine, is an amino amide local anesthetic. When administered to humans intravenously , it is capable of inhibiting the plasma cholinesterase ( butyrylcholinesterase ) enzyme.
Zam-Buk is a patent medicine which was produced by the Zam-Buk Company of Leeds, England, founded by Charles Edward Fulford.It was first sold by his Bile Beans company in 1902, [1] as a herbal balm and antiseptic ointment; the use of a complementary Zam-Buk soap was recommended to augment the treatment.
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