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Alexander A. Borbély (born 1939 in Budapest) is a Hungarian-Swiss pharmacologist known for his sleep research.. Borbély proposed the two-process model of sleep regulation in 1982 which postulates there are two complementary processes (S and C, which stands for Sleep and Circadian, respectively) which together account for one's sleep schedule. [1]
In 1993, a different model called the opponent process model [98] was proposed. This model explained that these two processes opposed each other to produce sleep, as against Borbely's model. According to this model, the SCN, which is involved in the circadian rhythm, enhances wakefulness and opposes the homeostatic rhythm.
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This model proposes a homeostatic process (Process S) and a circadian process (Process C) that interact to define the time and intensity of sleep. [71] Process S represents the drive for sleep, increasing during wakefulness and decreasing during sleep until a defined threshold level, while Process C is the oscillator responsible for these levels.
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