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On 23 January 2006, an FDA advisory panel voted 11 to 3 to recommend the approval of an OTC formulation of orlistat, to be sold under the brand name Alli by GlaxoSmithKline. [41] Approval was granted on 7 February 2007, [42] and Alli became the first weight loss drug officially sanctioned by the U.S. government for over-the-counter use. [43]
Originally available only by prescription, it was approved by the FDA for over-the-counter sale in February 2007. [32] In May 2010, the U.S. Food and Drug Administration (FDA) approved a revised label for Xenical to include new safety information about rare cases of severe liver injury that have been reported with the use of this medication. [ 33 ]
In January 2010, a similar alert was issued for counterfeit versions of the over-the-counter weight loss drug Alli sold over the Internet. Instead of the active ingredient orlistat , the counterfeit drugs contain sibutramine, and at concentrations at least twice the amount recommended for weight loss.
There are positives to this effect—namely weight loss, but also potentially treating substance use and addiction, likely due to GLP-1s’ effect on the hypothalamus.
PHOTO: Semaglutide (GLP-1) weight-loss drug Wegovy, made by pharmaceutical company Novo Nordisk is seen on Oct. 16, 2024. (James Manning/PA Images via Getty Images)
They are prescription GLP-1 agonists that promote weight loss by slowing digestion and reducing appetite, says Lee. Both medications have undergone testing and received approval by the U.S. Food ...
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