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Paraoxon and rivastigmine are both acetylcholinesterase inhibitors and butyrylcholinesterase inhibitors. [14] [11] [7]In 2015, the United States Food and Drug Administration's Adverse Event Reporting System database compared rivastigmine to the other ChEI drugs donepezil and galantamine found that rivastigmine was associated with a higher frequency of reports of death as an adverse event.
Donepezil, sold under the brand name Aricept among others, is a medication used to treat dementia of the Alzheimer's type. [3] [4] [8] It appears to result in a small benefit in mental function and ability to function. [9] Use, however, has not been shown to change the progression of the disease. [10] Treatment should be stopped if no benefit ...
Benzgalantamine is a prodrug of galantamine. [1] The most common side effects include nausea, vomiting, diarrhea, dizziness, headache, and decreased appetite. [1] Benzgalantamine was approved for medical use in the United States in July 2024. [1] [2] [3]
Galantamine is a type of acetylcholinesterase inhibitor.It is an alkaloid extracted from the bulbs and flowers of Galanthus nivalis (common snowdrop), Galanthus caucasicus (Caucasian snowdrop), Galanthus woronowii (Voronov's snowdrop), and other members of the family Amaryllidaceae, such as Narcissus (), Leucojum aestivum (snowflake), and Lycoris including Lycoris radiata (red spider lily). [5]
Memantine/donepezil, sold under the brand name Namzaric among others, is a fixed dose combination medication used for the treatment of dementia of the Alzheimer's type. [1] It contains memantine , as the hydrochloride, a NMDA receptor antagonist ; and donepezil as the hydrochloride, an acetylcholinesterase inhibitor . [ 1 ]
The effects of donepezil, galantamine and rivastigmine have all been assessed but, overall, the findings have been inconsistent, and it is estimated that apathy in ~60% of Alzheimer's patients does not respond to treatment with these drugs. [7]
In the Medical Uses section, it would be helpful to note that the US FDA approved donepezil for mild, moderate, and severe dementia in Alzheimer's, rather than just severe dementia. In the Adverse Effects section, some of the sentences need references, and adding in the frequencies for each of the mentioned adverse effects would be helpful.
C 40 H 48 N 4 O 2: Molar mass: 616.850 g·mol −1 ... 19,20-dihydrotabernamine is said to have potent acetylcholinesterase inhibitor activity greater than galantamine.
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