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Dopamine agonists are mainly used to treat Parkinson's disease, but also hyperprolactinemia and restless legs syndrome. [15] The side effects are predominantly collected from studies of Parkinson's disease, where dopamine agonists are commonly used as a first-line treatment with levodopa. [16]
Pharmacological treatment of Parkinson's disease. The main families of drugs useful for treating motor symptoms are levodopa, dopamine agonists, and MAO-B inhibitors. [3] The most commonly used treatment approach varies depending on the disease stage.
Parkinson’s disease, which is lifelong, progressive, and has no cure, occurs when brain cells that make dopamine, a chemical that coordinates movement, stop working or die, according to the ...
Bromocriptine, originally marketed as Parlodel and subsequently under many brand names, [1] is an ergoline derivative and dopamine agonist that is used in the treatment of pituitary tumors, Parkinson's disease, hyperprolactinaemia, neuroleptic malignant syndrome, and, as an adjunct, type 2 diabetes.
One dopamine precursor, Levodopa, was the first drug approved specifically for Parkinson's disease. [2] DRT increases dopamine in the brain to optimal levels in order to return motor skills, impulsivity, and decision making to normal function. [3] Although DRT can improve motor skills and decision making in patients with mild to severe ...
Ergot dopamine agonists were commonly used, but have been largely replaced with non-ergot compounds due to severe adverse effects like pulmonary fibrosis and cardiovascular issues. [175] Non-ergot agonists are efficacious in both early and late stage Parkinson's, [176] The agonist apomorphine is often used for drug-resistant OFF time in later ...
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