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Phage therapy is the use of bacteriophages to treat bacterial infections. Bacteriophage treatment offers a possible alternative to conventional antibiotic treatments for bacterial infection. [55] It is conceivable that, although bacteria can develop resistance to phages, the resistance might be easier to overcome than resistance to antibiotics.
George Eliava pioneered the use of phages in treating bacterial infections. Phages were discovered to be antibacterial agents and were used in the former Soviet Republic of Georgia (pioneered there by Giorgi Eliava with help from the co-discoverer of bacteriophages, Félix d'Hérelle) during the 1920s and 1930s for treating bacterial infections.
Phage therapy is the method by which bacteriophages (viruses which infect bacteria) are used to treat bacterial infections or reduce bacterial populations. Phage therapy has gained recent attention in the United States as an alternative to standard antibiotic therapy.
Mycobacteriophage Bxb1 Structure [1]. A mycobacteriophage is a member of a group of bacteriophages known to have mycobacteria as host bacterial species. While originally isolated from the bacterial species Mycobacterium smegmatis and Mycobacterium tuberculosis, [2] the causative agent of tuberculosis, more than 4,200 mycobacteriophage species have since been isolated from various environmental ...
The bacteria are infected with phages and die, producing new phages; the medium clears. The medium is filtered through porcelain filter, holding back bacteria and larger objects; only the smaller phages pass through. In early 1919, d'Hérelle isolated phages from chicken feces, successfully treating a plague of chicken typhoid with them. [13]
Fischetti is known for his role as the "father" of phage lysins as therapeutics, with his laboratory being the first to use phage lysins in animal models to prevent and treat infections. [ 27 ] [ 28 ] [ 29 ] His studies on the M protein of Streptococcus pyogenes also revealed basic discoveries on the way surface proteins on gram-positive ...
Filamentous phages, unlike most other phages, are continually extruded through the bacterial membrane without killing the host. [19] Genetic studies on M13 using conditional lethal mutants, initiated by David Pratt and colleagues, led to description of phage gene functions.
Because phages have coevolved with their bacterial hosts, the endolysin system is very efficient at degrading bacterial cell walls. [3] Phages release endolysins from inside bacterial host cells that cleave the peptidoglycan bonds of the bacterial cell wall. [4] Once the cell is lysed, the bacteriophage is able to release progeny virions into ...
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