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The human protein is also frequently referred to as HER2 (human epidermal growth factor receptor 2) or CD340 (cluster of differentiation 340). [5] [6] [7]
Dennis Joseph Slamon (born August 6, 1948), [1] [2] is an American oncologist and chief of the division of Hematology-Oncology at UCLA.He is best known for his work identifying the HER2/neu oncogene that is amplified in 25–33% of breast cancer patients and the resulting treatment trastuzumab.
The epidermal growth factor receptor is a member of the ErbB family of receptors, a subfamily of four closely related receptor tyrosine kinases: EGFR (ErbB-1), HER2/neu (ErbB-2), Her 3 (ErbB-3) and Her 4 (ErbB-4). In many cancer types, mutations affecting EGFR expression or activity could result in cancer. [6]
The following is a table of drugs organized by their year of discovery. Naturally occurring chemicals in plants, including alkaloids, have been used since pre-history.In the modern era, plant-based drugs have been isolated, purified and synthesised anew.
Luminal B is also typically HER2 negative. HER2 is the protein that helps breast cancer cells grow, per the American Cancer Society . When it's negative, that means the cancer isn't likely to ...
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According to the American Cancer Society, 1 in every 8 women in the United States will develop breast cancer at some time in their life, with most cases occurring in women over the age of 50.
1869: Friedrich Miescher discovers a weak acid in the nuclei of white blood cells that today we call DNA. In 1871 he isolated cell nuclei, separated the nucleic cells from bandages and then treated them with pepsin (an enzyme which breaks down proteins). From this, he recovered an acidic substance which he called "nuclein". [1]