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Allopurinol is used to reduce urate formation in conditions where urate deposition has already occurred or is predictable. The specific diseases and conditions where it is used include gouty arthritis, skin tophi, kidney stones, idiopathic gout; uric acid lithiasis; acute uric acid nephropathy; neoplastic disease and myeloproliferative disease with high cell turnover rates, in which high urate ...
Lesinurad (brand name Zurampic) is a urate transporter inhibitor for treating high blood uric acid levels associated with gout. [2] It is recommended only as an adjuvant with either allopurinol or febuxostat when these medications are not sufficient. [3] It received FDA approval on 22 December 2015. [3]
Drugs with other primary uses, that have known uricosuric properties, include losartan, [1] atorvastatin, and fenofibrate.Although these drugs may have significant uricosuric action, their other significant pharmacological actions in off-label use as a uricosuric requires careful assessment of the patient to achieve the most benefit and least risk.
Gout is an inflammatory form of arthritis that can occur when there’s too much uric acid in the body. Uric acid is a normal waste product made by the body, but in some people, it can accumulate ...
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Allopurinol is used in dogs with altered purine metabolism to prevent the formation of uric acid. Feeding a diet high in purines while simultaneously administering allopurinol can result in the formation of xanthine (C 5 H 4 N 4 O 2 ) stones.
Adult dogs Most adult dogs need to pee about three to five times a day. Factors such as size, breed, and activity level affect urination frequency. Lots of dogs like to pee on things when they are ...
A xanthine oxidase inhibitor is any substance that inhibits the activity of xanthine oxidase, an enzyme involved in purine metabolism.In humans, inhibition of xanthine oxidase reduces the production of uric acid, and several medications that inhibit xanthine oxidase are indicated for treatment of hyperuricemia and related medical conditions including gout. [1]