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Gout is an inflammatory form of arthritis that can occur when there’s too much uric acid in the body. ... allopurinol is the first-line medication for lowering uric acid levels. Febuxostat is ...
] The safety trial was conducted in over 6,000 patients with gout treated with either febuxostat or allopurinol. The primary outcome was a combination of heart-related death, non-deadly heart attack, non-deadly stroke, and a condition of inadequate blood supply to the heart requiring urgent surgery.
Allopurinol is used to reduce urate formation in conditions where urate deposition has already occurred or is predictable. The specific diseases and conditions where it is used include gouty arthritis, skin tophi, kidney stones, idiopathic gout; uric acid lithiasis; acute uric acid nephropathy; neoplastic disease and myeloproliferative disease with high cell turnover rates, in which high urate ...
Drugs with other primary uses, that have known uricosuric properties, include losartan, [1] atorvastatin, and fenofibrate.Although these drugs may have significant uricosuric action, their other significant pharmacological actions in off-label use as a uricosuric requires careful assessment of the patient to achieve the most benefit and least risk.
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Once the acute attack resolves, levels of uric acid can be lowered via lifestyle changes or allopurinol. [3] Taking vitamin C and eating a diet high in low-fat dairy products may be preventive. [ 7 ]
Gout presenting as slight redness in the metatarsophalangeal joint of the big toe. Gout can present in several ways, although the most common is a recurrent attack of acute inflammatory arthritis (a red, tender, hot, swollen joint). [4] The metatarsophalangeal joint at the base of the big toe is affected most often, accounting for half of cases ...
A leaked video of UnitedHealth CEO Andrew Witty defending claim denials after Brian Thompson’s murder has sparked backlash. Critics argue the policy contributes to medical bankruptcies and lives ...
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