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Carcinogenic parasites are parasitic organisms that depend on other organisms (called hosts) for their survival, and cause cancer in such hosts.Three species of flukes are medically-proven carcinogenic parasites, namely the urinary blood fluke (Schistosoma haematobium), the Southeast Asian liver fluke (Opisthorchis viverrini) and the Chinese liver fluke (Clonorchis sinensis).
Clonorchis sinensis under a light microscope: Notice the uterus; this species is monoecious. An adult C. sinensis is a flattened (dorsoventrally) and leaf-shaped fluke. The body is slightly elongated and slender, measuring 15–20 mm in length and 3–4 mm in width. [10]
The larvae are released into the environment from which the definitive hosts (humans and other mammals) acquire the infection. In some species another intermediate host is required, generally a cyprinid fish, and the definitive hosts are infected from eating infected fish. Hence, these species are food-borne parasites.
Clonorchis sinensis; Clonorchis viverrini: gall bladder ducts and inflammation of liver East Asia ingestion of under prepared freshwater fish Lancet liver fluke Dicrocoelium dendriticum: gall bladder rare ingestion of ants Liver fluke – Fasciolosis [9] Fasciola hepatica, Fasciola gigantica: liver, gall bladder stool
The second intermediate host include freshwater fish: Mugil cephalus, Tilapia nilotica, Aphanius fasciatus, and Acanthogobius sp. [6] The definitive host, such as humans or birds, eats the undercooked or raw meat of a fish and ingest the parasite. Natural definitive hosts are cats, dogs, foxes, wolves, pelicans, and humans. [6]
Clonorchis sinensis is a trematode (fluke) which is part of the phylum Platyhelminthes. The parasitic worm is as long as 10 to 25 mm and lives in the bile ducts of the liver. It is a hermaphroditic fluke that requires two intermediate hosts. The eggs of the worms are passed in fecal matter into a body of water and are then ingested by mollusks.
In three-host life cycles, cercariae develop in the second intermediate host into a resting stage, the metacercaria, which is usually encysted in a cyst of host and parasite origin, or encapsulated in a layer of tissue derived from the host only. This stage is infective to the definitive host. Transmission occurs when the definitive host preys ...
These include the human papillomavirus, which is associated with cervical carcinoma and nasopharyngeal carcinoma; Epstein-Barr virus, which is associated with a variety of Epstein-Barr virus-associated lymphoproliferative lymphomas; Kaposi's sarcoma herpesvirus, which is associated with Kaposi's sarcoma and primary effusion lymphoma; hepatitis ...
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