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The endoplasmic reticulum is found in most eukaryotic cells and forms an interconnected network of flattened, membrane-enclosed sacs known as cisternae (in the RER), and tubular structures in the SER. The membranes of the ER are continuous with the outer nuclear membrane. The endoplasmic reticulum is not found in red blood cells, or spermatozoa.
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The endoplasmic reticulum (ER) is a synthesis and transport organelle that branches into the cytoplasm in plant and animal cells. [3] The Golgi apparatus is a series of multiple compartments where molecules are packaged for delivery to other cell components or for secretion from the cell. [ 4 ]
While the two membranes and the endoplasmic reticulum are linked, proteins embedded in the membranes tend to stay put rather than dispersing across the continuum. [18] It is lined with a fiber network called the nuclear lamina which is 10-40 nm thick and provides strength. [citation needed]
Masses of rough endoplasmic reticulum also occur in some non-neuronal cells, where they are referred to as ergastoplasm, basophilic bodies, [1] or chromophilic substance. [4] While these organelles differ in some ways from Nissl bodies in neurons, [5] large amounts of rough endoplasmic reticulum are generally linked to the copious production of ...
STIM1 is a Ca 2+-sensor protein specialized for electrical signaling in the endoplasmic reticulum (ER). [6] It interacts with and mediates store-dependent regulation of both Orai1 and TRPC1 channels. TRPC1+STIM1-dependent SOC requires functional Orai1. [7] STIM1 is the mechanistic 'missing link' between the ER and the plasma membrane.
SERCA is a P-type ATPase. [1] It resides in the sarcoplasmic reticulum (SR) within myocytes. [1] It is a Ca 2+ ATPase that transfers Ca 2+ from the cytosol of the cell to the lumen of the SR. [1]
Ion channels are also classified according to their subcellular localization. The plasma membrane accounts for around 2% of the total membrane in the cell, whereas intracellular organelles contain 98% of the cell's membrane. The major intracellular compartments are endoplasmic reticulum, Golgi apparatus, and mitochondria. On the basis of ...
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