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Acceptable daily intake or ADI is a measure of the amount of a specific substance (originally applied for a food additive, later also for a residue of a veterinary drug or pesticide) in food or drinking water that can be ingested (orally) daily over a lifetime without an appreciable health risk. [1]
For the drugs administered by oral and dermal route, the units of threshold dose are mg/kg body-weight/day (dose of the drug in mg per body weight in kg per day) or ppm (parts per million), while the threshold dose of drugs by inhalation delivery has the unit of mg/L 6h/day (amount of drug in mg in 1L of air, for 6 hours per day). [8]
As with the acute RfD, the chronic RfD of 3×10 −4 mg/kg/day was determined by dividing this NOAEL by the inter- and intraspecies uncertainty factors. The chronic PAD ("cPAD") of 3×10 −5 mg/kg/day was determined by applying an additional 10-fold uncertainty factor to account for the increased susceptibility of infants and children. Like ...
The JECFA makes a distinction between acceptable intakes and tolerable intakes. Tolerable is used to demonstrate permissibility, not acceptability. [3] Substances such as food additives, veterinary drugs, and pesticides that can be controlled in the food supply relatively easily are assessed an acceptable daily intake, or ADI.
every day (once daily) (preferred to "qd" in the UK [10]) o.d. oculus dexter: right eye o can be mistaken as an a which could read "a.d.", meaning right ear, confusion with "omni die" o.m. omni mane: every morning omn. bih. omni bihora: every 2 hours omn. hor. omni hora: every hour o.n. omni nocte: every night OPD once per day o.s.
100, 300, 600, and 900 mg/kg/day Reduced maternal body weight gain from 73 g in controls to 48 and 43 g in the 600 and 900 mg/kg/day dose groups, respectively. [42] Wistar Rats Oral (by gavage) 600 mg/kg bw/day Reductions in fetal plasma leptin levels and in fetal insulin levels. Prenatal exposure disrupts fetal testosterone production in male ...
Download as PDF; Printable version; In other projects ... at 1.75 milligrams per kilogram of body weight per day (mg/kg/bw ... of text saying certain studies had ...
Human body weight is a person's mass or weight.. Strictly speaking, body weight is the measurement of mass without items located on the person. Practically though, body weight may be measured with clothes on, but without shoes or heavy accessories such as mobile phones and wallets, and using manual or digital weighing scales.