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Peptic ulcer disease is when the inner part of the stomach's gastric mucosa (lining of the stomach), the first part of the small intestine, or sometimes the lower esophagus, gets damaged. An ulcer in the stomach is called a gastric ulcer , while one in the first part of the intestines is a duodenal ulcer . [ 1 ]
G. Bottcher and M. Letulle hypothesize that ulcers are caused by bacteria. [1] 1880 J. Cohnheim suggests that ulcers may be caused by chemical factors. [1] 1881 Klebs notes the presence of bacteria-like organisms in the lumen of the gastric glands. [4] 1889 Walery Jaworski describes spiral organisms in sediment washings of humans. He suggests ...
Prolonged bleeding may cause anemia leading to weakness and fatigue. Inflammation of the pyloric antrum, which connects the stomach to the duodenum, is more likely to lead to duodenal ulcers, while inflammation of the corpus may lead to a gastric ulcer. Stomach cancer can cause nausea, vomiting, diarrhoea, constipation, and unexplained weight ...
“A peptic ulcer is a sore or a break in the tissue that lines your stomach or small intestine,” explains Dr. Leah DeCoste, MD, a gastroenterologist with Gastro Health in Acton, Massachusetts ...
Peptic ulcer disease Ulcers cause breaks in the mucosa and cause erosion of the sub-mucosa. Zollinger-Ellison syndrome Gastrin levels increase due to tumors, which cause an increase in the gastric fold size. [7] Ménétrier's disease The mucosa pits are in excess causing thickening of the folds. [7] Carcinoma Helicobacter pylori infection
Many stomach diseases are associated with infections. In the past it was widely but incorrectly believed that the highly acidic environment of the stomach would keep the stomach immune from infection. Many studies have indicated that most cases of stomach ulcers, gastritis, and stomach cancer are caused by Helicobacter pylori infection.
A large hiatal hernia. Two x-rays from the same examination. On lying down (A) more stomach slides above the diaphragm than when upright (B) Note constriction of stomach at diaphragm level. Cameron lesions. A long linear erosion and smaller non-linear erosions on the crests of inflamed gastric folds at the level of the diaphragm.
The stomach often dilates to accommodate food intake and secretions. Causes of gastric outlet obstruction include both benign causes, such as peptic ulcer disease affecting the area around the pylorus, and malignant causes, such as gastric cancer .