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Absorption half-life 1 h, elimination half-life 12 h. Biological half-life (elimination half-life, pharmacological half-life) is the time taken for concentration of a biological substance (such as a medication) to decrease from its maximum concentration (C max) to half of C max in the blood plasma.
In this situation it is generally uncommon to talk about half-life in the first place, but sometimes people will describe the decay in terms of its "first half-life", "second half-life", etc., where the first half-life is defined as the time required for decay from the initial value to 50%, the second half-life is from 50% to 25%, and so on. [7]
C 0 is the initial concentration (at t=0) t 1/2 is the half-life time of the drug, which is the time needed for the plasma drug concentration to drop to its half; Therefore, the amount of drug present in the body at time t is;
A more intuitive characteristic of exponential decay for many people is the time required for the decaying quantity to fall to one half of its initial value. (If N(t) is discrete, then this is the median life-time rather than the mean life-time.) This time is called the half-life, and often denoted by the symbol t 1/2. The half-life can be ...
Alternatively, since the radioactive decay contributes to the "physical (i.e. radioactive)" half-life, while the metabolic elimination processes determines the "biological" half-life of the radionuclide, the two act as parallel paths for elimination of the radioactivity, the effective half-life could also be represented by the formula: [1] [2]
But is also equivalent to divided by elimination rate half-life /, = /. Thus, C l t o t = ln 2 ⋅ V d t 1 / 2 {\displaystyle Cl_{tot}={\dfrac {\ln 2\cdot V_{d}}{t_{1/2}}}} . This means, for example, that an increase in total clearance results in a decrease in elimination rate half-life, provided distribution volume is constant.
The initial phase half-life is approximately 1 minute and the terminal half-life is approximately 15 minutes. ... (7.5% vs 82.7%) and a 92.5% rate of success in ...
The plasma half-life or half life of elimination is the time required to eliminate 50% of the absorbed dose of a drug from an organism. Or put another way, the time that it takes for the plasma concentration to fall by half from its maximum levels.