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CAR T Cell Therapies with Regulatory Approval; CAR T cell (Brand name) Company Approval Agency: Date Target Antigen recognition domain Intracellular signaling domain Indication (Targeted disease / Line of Therapy) Agency Product Number, Drug Label tisagenlecleucel (Kymriah) Novartis: FDA: 08/30/2017 [49] EMA: 08/22/2018 [50] MHLW: 05/15/2019 ...
The safety and efficacy of ciltacabtagene autoleucel were evaluated in CARTITUDE-1 (NCT03548207), an open label, multicenter clinical trial evaluating ciltacabtagene autoleucel in 97 participants with relapsed or refractory multiple myeloma who received at least three prior lines of therapy which included a proteasome inhibitor, an immunomodulatory agent, and an anti-CD38 monoclonal antibody ...
CAR-T kill tumor cells specifically by targeting the tumor-associated antigens to keep the damage to healthy tissue at a minimum level. Additionally, these engineered T-cells can perform their function independent from HLA - major histocompatibility complex (MHC) presentation. Furthermore, CAR structure can be manipulated flexibly to target ...
Engineered chimeric antigen receptor (CAR)-T cell delivery is the methodology by which clinicians introduce the cancer-targeting therapeutic system of the CAR-T cell to the human body. CAR-T cells, which utilizes genetic modification of human T-cells to contain antigen binding sequences in addition to the receptor systems CD4 or CD8 , are ...
Watch manufacturing companies of India (5 P) Pages in category "Manufacturing companies of India" The following 31 pages are in this category, out of 31 total.
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Bharat Biotech has its manufacturing facility situated at Genome Valley, Hyderabad, India. [5] As of July 2020, the company has over 700 employees [6] and has a presence worldwide. [5] The company has been responsible for developing an eco-friendly recombinant [7] and a naturally attenuated strain derived Rotavirus vaccine called ROTAVAC.
LifeCell International is an Indian biotechnology company established in 2004. [1] [2] It runs India's largest stem cell bank and has also diversified into diagnostics and tissue therapeutics. [1] In 2017 the company launched a community stem cell banking which allows sharing of preserved umbilical cord stem cells among its members. [2]