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In humans, the CCR5 gene that encodes the CCR5 protein is located on the short (p) arm at position 21 on chromosome 3. Certain populations have inherited the Delta 32 mutation, resulting in the genetic deletion of a portion of the CCR5 gene. Homozygous carriers of this mutation are resistant to infection by macrophage-tropic (M-tropic) strains ...
The continued spread of the SARS-CoV-2 virus has spawned a Greek alphabet of variants - a naming system used by the World Health Organization to track concerning new mutations of the virus that ...
The Delta variant (B.1.617.2) was [3] [4] a variant of SARS-CoV-2, the virus that causes COVID-19. It was first detected in India on 5 October 2020. The Delta variant was named on 31 May 2021 and had spread to over 179 countries by 22 November 2021.
Scientists have pinpointed 16 new genetic variants in people who developed severe COVID-19 in a large study that could help researchers develop treatments for very sick patients.
The variant, called "Delta with K417N" by Public Health England, includes two clades corresponding to the Pango lineages AY.1 and AY.2. [151] It has been nicknamed "Delta plus" [152] from "Delta plus K417N". [153] The name of the mutation, K417N, refers to an exchange whereby lysine (K) is replaced by asparagine (N) at position 417. [154]
The absence of such receptors, or rather the shortening of them to the point of being inoperable, is known as the delta 32 mutation. [4] This mutation is linked to groups of people that have been exposed to HIV but remain uninfected such as some offspring of HIV positive mothers, health officials, and sex workers. [5]
While the alpha and beta genera are derived from the bat viral gene pool, the gamma and delta genera are derived from the avian and pig viral gene pools. [1] Recombination appears to be common among deltacoronaviruses. [2] Recombination occurs frequently in the viral genome region that encodes the host receptor binding protein.
The treatment and management of COVID-19 combines both supportive care, which includes treatment to relieve symptoms, fluid therapy, oxygen support as needed, [1] [2] [3] and a growing list of approved medications.