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Sorafenib is a small molecule inhibitor of many tyrosine kinase receptors such as VEGFR-2. Side effects are in most cases mild to moderate such as rash, hand-foot skin reaction, diarrhea and dermatitis, and occur in about 33-38% patients using sorafenib. Other side effects are mild hypertension, leukopenia and bleeding. Uncommon side effects ...
Targeted therapy of lung cancer refers to using agents specifically designed to selectively target molecular pathways responsible for, or that substantially drive, the malignant phenotype of lung cancer cells, and as a consequence of this (relative) selectivity, cause fewer toxic effects on normal cells.
While lung cancer is the deadliest type of cancer, it receives the third-most funding from the US National Cancer Institute (NCI, the world's largest cancer research funder) behind brain cancers and breast cancer. [117] Despite high levels of gross research funding, lung cancer funding per death lags behind many other cancers, with around ...
The causes of SIADH are commonly grouped into categories including: central nervous system diseases that directly stimulate the hypothalamus to release ADH, various cancers that synthesize and secrete ectopic ADH, various lung diseases, numerous drugs (carbamazepine, cyclophosphamide, SSRIs) that may stimulate the release of ADH, vasopressin ...
Pulmonary toxicity is the medical name for side effects on the lungs. Although most cases of pulmonary toxicity in medicine are due to side effects of medicinal drugs, many cases can be due to side effects of radiation (radiotherapy). Other (non-medical) causes of pulmonary toxicity can be chemical compounds and airborne particulate matter.
Carbamazepine, or Tegretol, has been used as a mood stabilizer and is accepted treatment for bipolar disorder. [6] Clomiphene (Clomid) for male infertility: clomiphene is approved for female infertility due to ovulatory disorder. Clonidine (Catapres) for ADHD: clonidine is approved and commonly used for the treatment of hypertension. Other off ...
Some make use of SBRT (stereotactic body radiation therapy), a very precise radiation technique able to provide high doses with minimal side effects. Most trials of LCT in NSCLC focus on oligometastatic disease (under 3-5 lesions, depending on the definitions), but preliminary results of the BRIGHTSTAR trial [ 24 ] indicate this method may be ...
The symptoms of DRESS syndrome usually begin 2 to 6 weeks but uncommonly up to 8–16 weeks after exposure to an offending drug. Symptoms generally include fever, an often itchy rash which may be morbilliform or consist mainly of macules or plaques, facial edema (i.e. swelling, which is a hallmark of the disease), enlarged and sometimes painful lymph nodes, and other symptoms due to ...