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The rough endoplasmic reticulum works in concert with the Golgi complex to target new proteins to their proper destinations. The second method of transport out of the endoplasmic reticulum involves areas called membrane contact sites, where the membranes of the endoplasmic reticulum and other organelles are held closely together, allowing the ...
Secretory pathway diagram, including nucleus, endoplasmic reticulum and golgi apparatus. Nuclear membrane; Nuclear pore; Rough endoplasmic reticulum (rER) Smooth endoplasmic reticulum (sER) Ribosome attached to rER; Macromolecules; Transport vesicles; Golgi apparatus; Cis face of Golgi apparatus; Trans face of Golgi apparatus; Cisternae of ...
Masses of rough endoplasmic reticulum also occur in some non-neuronal cells, where they are referred to as ergastoplasm, basophilic bodies, [1] or chromophilic substance. [4] While these organelles differ in some ways from Nissl bodies in neurons, [5] large amounts of rough endoplasmic reticulum are generally linked to the copious production of ...
Rough (containing ribosomes) and smooth (without ribosomes) microsomes are made from the endoplasmic reticulum through cell disruption. These microsomes have an inside that is exactly the same as the endoplasmic reticulum lumen. Both forms of microsomes can be purified by a process known as equilibrium density centrifugation. Rough and smooth ...
The soma of a neuron (i.e., the main part of the neuron in which the dendrites branch off of) contains many organelles, including granules called Nissl granules, which are composed largely of rough endoplasmic reticulum and free polyribosomes. [5] The cell nucleus is a key feature of the soma.
Abundant rough endoplasmic reticulum combined with a well-developed Golgi apparatus makes plasma cells well-suited for secreting immunoglobulins. [4] Other organelles in a plasma cell include ribosomes, lysosomes, mitochondria, and the plasma membrane.
The rough endoplasmic reticulum is so named because the cytoplasmic surface is covered with ribosomes, giving it a bumpy appearance when viewed through an electron microscope. The smooth ER appears smooth since its cytoplasmic surface lacks ribosomes.
They measure 1–3 μm in diameter. Not much is known about their formation, but they are thought to be remnants of the rough endoplasmic reticulum. [citation needed] They are named after German pathologist, Karl Gottfried Paul Döhle (1855–1928). [1] [2] They are often present in conjunction with toxic granulation. [3]