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White matter is the tissue through which messages pass between different areas of grey matter within the central nervous system. The white matter is white because of the fatty substance (myelin) that surrounds the nerve fibers (axons). This myelin is found in almost all long nerve fibers, and acts as an electrical insulation.
The uncinate fasciculus is a white matter association tract in the human brain that connects parts of the limbic system such as the temporal pole, anterior parahippocampus, and amygdala in the temporal lobe with inferior portions of the frontal lobe such as the orbitofrontal cortex.
It is a region formed by several grey matter nuclei and their associated white matter structures, namely: [3] The subthalamic nucleus, whose neurons contain glutamate and have excitatory effects over neurons of globus pallidus and substantia nigra; Zona incerta, located between fields of Forel H 1 and H 2.
It is the largest white matter structure in the human brain, about 10 cm (3.9 in) in length and consisting of 200–300 million axonal projections. [2] [3] A number of separate nerve tracts, classed as subregions of the corpus callosum, connect different parts of the hemispheres.
Broca's area – region of the brain with functions linked to speech production Triangular part of inferior frontal gyrus – part of Broca's area that contributes to propositional (true/false) language comprehension; Caudate nucleus – located within the basal ganglia and involved in learning and memory
Brain at the U.S. National Library of Medicine Medical Subject Headings (MeSH) (view tree for regions of the brain) BrainMaps.org; BrainInfo (University of Washington) "Brain Anatomy and How the Brain Works". Johns Hopkins Medicine. 14 July 2021. "Brain Map". Queensland Health. 12 July 2022.
In humans, the cerebrum is the largest and best-developed of the five major divisions of the brain. The cerebrum is made up of the two cerebral hemispheres and their cerebral cortices (the outer layers of grey matter), and the underlying regions of white matter. [2] Its subcortical structures include the hippocampus, basal ganglia and olfactory ...
TSC1 or TSC2 inactivation can cause TSC and the associated tumors in the brain. When inactivation of TSC1 is present during corticogenesis, malformations of cortical tubers, or abnormal benign tissue growth, along with white matter nodes would form in mice. This replicates the effect TSC is found to have in humans afflicted with TSC.