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HCMV antiviral drug resistance can be detected by phenotypic or by genotypic drug resistance testing. Phenotypic resistance testing involves cultivation of the virus in cell culture and testing its susceptibility using different antiviral drug concentrations in order to determine EC50 values.
In the past nucleic acid tests have mainly been used as a secondary test to confirm positive serological results. [3] However, as they become cheaper and more automated, they are increasingly becoming the primary tool for diagnostics and can also be use for monitoring of treatment of viral infected individuals t.
Human coronavirus OC43 [1] (HCoV-OC43) is a member of the species Betacoronavirus 1, which infects humans and cattle. [2] [3] The infecting coronavirus is an enveloped, positive-sense, single-stranded RNA virus that enters its host cell by binding to the N-acetyl-9-O-acetylneuraminic acid receptor. [4]
List of Antiviral Drugs Antiviral Use Manufacturer Component Type Year approved Abacavir: HIV: ViiV Healthcare: Nucleoside analogue reverse transcriptase inhibitor (NRTI) 1998 Acyclovir (Aciclovir) Herpes Simplex, chickenpox, [2] varicella zoster virus: GSK: guanosine analogue RTI 1981 Adefovir: Hepatitis B [3] Gilead Sciences RTI 2002 , 2003 ...
Congenital cytomegalovirus (cCMV) is cytomegalovirus (CMV) infection in a newborn baby. [1] Most have no symptoms. [1] Some affected babies are small. [1] Other signs and symptoms include a rash, jaundice, hepatomegaly, retinitis, and seizures. [1] [2] It may lead to loss of hearing or vision, developmental disability, or a small head. [1]
Ganciclovir is commonly associated with a range of serious haematological adverse effects. Common adverse drug reactions (≥1% of patients) include: granulocytopenia, neutropenia, anaemia, thrombocytopenia, fever, nausea, vomiting, dyspepsia, diarrhea, abdominal pain, flatulence, anorexia, raised liver enzymes, headache, confusion, hallucination, seizures, pain and phlebitis at injection site ...