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Treatment effect An effect attributed to a treatment in a clinical trial. In most clinical trials the treatment effect of interest is a comparison (or contrast) of two or more treatments. (ICH E9) Treatment emergent An event that emerges during treatment having been absent pre-treatment, or worsens relative to the pre-treatment state. (ICH E9)
Effect (of a factor): How changing the settings of a factor changes the response. The effect of a single factor is also called a main effect. A treatment effect may be assumed to be the same for each experimental unit, by the assumption of treatment-unit additivity; more generally, the treatment effect may be the average effect.
Clinical research is different from clinical practice: in clinical practice, established treatments are used to improve the condition of a person, while in clinical research, evidence is collected under rigorous study conditions on groups of people to determine the efficacy and safety of a treatment.
Dr. A. Thomas McLellan, the co-founder of the Treatment Research Institute, echoed that point. “Here’s the problem,” he said. Treatment methods were determined “before anybody really understood the science of addiction. We started off with the wrong model.” For families, the result can be frustrating and an expensive failure.
Artistic research, also seen as 'practice-based research', can take form when creative works are considered both the research and the object of research itself. It is the debatable body of thought which offers an alternative to purely scientific methods in research in its search for knowledge and truth.
Community-based research is more likely to trigger public action and engagement with environmental issues than traditional research. [7] Bottom up community-based research in which community members oversee each phase of the research project is more likely to inspire structural reforms that are responsive to the needs of EJ communities. [6]
Evidence-based practice is the idea that occupational practices ought to be based on scientific evidence.The movement towards evidence-based practices attempts to encourage and, in some instances, require professionals and other decision-makers to pay more attention to evidence to inform their decision-making.
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