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Irritable bowel syndrome (IBS) is a functional gastrointestinal disorder characterized by a group of symptoms that commonly include abdominal pain, abdominal bloating and changes in the consistency of bowel movements. [1] These symptoms may occur over a long time, sometimes for years. [2]
Inflammatory bowel diseases are autoimmune diseases, in which the body's own immune system attacks elements of the digestive system. [57] The chief types of IBD are Crohn's disease (CD) and ulcerative colitis (UC). [ 58 ]
Irritable bowel disease (IBD), ... Only about 10% of the drugs to treat such inflammatory or autoimmune diseases that enter the clinical development stage become fully approved for treatment ...
This article provides a list of autoimmune diseases. These conditions, where the body's immune system mistakenly attacks its own cells, affect a range of organs and systems within the body. Each disorder is listed with the primary organ or body part that it affects and the associated autoantibodies that are typically found in people diagnosed ...
Other conditions with similar symptoms as Crohn's disease includes intestinal tuberculosis, Behçet's disease, ulcerative colitis, nonsteroidal anti-inflammatory drug enteropathy, irritable bowel syndrome and celiac disease. [10] Irritable bowel syndrome is excluded when there are inflammatory changes. [10]
The anti-TNF-α monoclonal antibody infliximab is a major biological therapy for inflammatory bowel diseaseBiological therapy, the use of medications called biopharmaceuticals or biologics that are tailored to specifically target an immune or genetic mediator of disease, plays a major role in the treatment of inflammatory bowel disease. [1]
In the case of autoimmune neuropathy, treatment with immunomodulatory therapies is done. If diabetes mellitus is the cause, control of blood glucose is important. [ 1 ] Treatment can include proton-pump inhibitors and H 2 receptor antagonists used for digestive symptoms such as acid reflux .
While Irritable bowel syndrome (IBS) is the only disease confirmed to be directly influenced by the gut microbiome, many disorders such as anxiety, autism, depression and schizophrenia have been linked to the gut-brain axis as well. [6] [36] [7]
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