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Debulking is the reduction of as much of the bulk of a tumour without the intention of a complete eradication. It is usually achieved by surgical removal. [1] [2] When performed for curative intent, it is a different procedure, which is called surgical debulking of tumors is known as cytoreduction or cytoreductive surgery [3] (CRS); "cytoreduction" refers to reducing the number of tumor cells.
Uterine clear cell tumors arise from an endometrium that has become thin and dry. [7] Patients usually present with abnormal uterine bleeding. Treatment of uterine clear cell carcinoma is primarily surgical. A tumor debulking procedure is typically performed, consisting of a total hysterectomy and bilateral salpingo-oopherectomy.
Cytoreductive "debulking" surgery may be performed prior to chemotherapy treatment in order to decrease the physical mass of the tumour and thus reduce the number of chemotherapy cycles needed. [39] The typical advanced presentation as well as extra-ovarian spread seen in HGSC can require aggressive debulking procedures. [ 51 ]
An alternative approach involves interval debulking surgery, which combines neoadjuvant chemotherapy with post-debulking chemotherapy. While laparoscopic surgery is suitable for early-stage cancer, advanced cases require more extensive procedures like lymphadenectomy. Secondary surgery may be an option for recurrent cases, effectiveness ...
The tumor is aggressive and spreads quickly into the myometrium and the lymphatic system. Thus even in presumed early stages, lymphadenectomy and omentectomy should be included in the surgical approach. If the tumor has spread surgery is cytoreductive followed by radiation therapy and/or chemotherapy. [4]
The largest recorded tumor that has ever been removed came from a woman in 1991. It weighed 302 pounds.Incredibly, the woman made a full recovery.
Ovarian cancer is highly treatable with surgery for almost all cases with well-differentiated stage-1 tumour. [4] [33] Higher tumour grades may benefit from adjuvant treatment such as platinum-based chemotherapy. [4] [33] Optimal debulking is used to treat cases where cancer has spread to become macroscopically advanced.
Carcinosarcoma of the uterus. In gross appearance, MMMTs are fleshier than adenocarcinomas, may be bulky and polypoid, and sometimes protrude through the cervical os.On histology, the tumors consist of adenocarcinoma (endometrioid, serous or clear cell) mixed with the malignant mesenchymal elements; alternatively, the tumor may contain two distinct and separate epithelial and mesenchymal ...