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  2. Mastocytosis - Wikipedia

    en.wikipedia.org/wiki/Mastocytosis

    Generalized eruption of cutaneous mastocytosis (adult type) is the most common pattern of mastocytosis presenting to the dermatologist, with the most common lesions being macules, papules, or nodules that are disseminated over most of the body but especially on the upper arms, legs, and trunk [13]

  3. Mast cell activation syndrome - Wikipedia

    en.wikipedia.org/wiki/Mast_cell_activation_syndrome

    Mast cell activation syndrome (MCAS) is a term referring to one of two types of mast cell activation disorder (MCAD); the other type is idiopathic MCAD. [1] MCAS is an immunological condition in which mast cells, a type of white blood cell, inappropriately and excessively release chemical mediators, such as histamine, resulting in a range of chronic symptoms, sometimes including anaphylaxis or ...

  4. Midostaurin - Wikipedia

    en.wikipedia.org/wiki/Midostaurin

    Over 95% of patients with adult onset systemic mastocytosis and approximately 40% of children with cutaneous mastocytosis are positive for the D816V c-Kit activating mutation, which renders c-Kit resistant to currently available tyrosine kinase inhibitors. Midostaurin is an investigational treatment in patients with advanced forms of systemic ...

  5. Avapritinib - Wikipedia

    en.wikipedia.org/wiki/Avapritinib

    Avapritinib, sold under the brand name Ayvakit among others, is a medication used for the treatment of advanced systemic mastocytosis and indolent systemic mastocytosis. It is also used for the treatment of tumors due to one specific rare mutation: it is specifically intended for adults with unresectable or metastatic gastrointestinal stromal tumor (GIST) that harbor a platelet-derived growth ...

  6. Mast cell stabilizer - Wikipedia

    en.wikipedia.org/wiki/Mast_cell_stabilizer

    Mast cell stabilizers are medications used to prevent or treat certain allergic disorders. They block mast cell degranulation, stabilizing the cell and thereby preventing the release of histamine and related mediators. One suspected pharmacodynamic mechanism is the blocking of IgE-regulated calcium channels. Without intracellular calcium, the ...

  7. Mast cell - Wikipedia

    en.wikipedia.org/wiki/Mast_cell

    A mast cell (also known as a mastocyte or a labrocyte [1]) is a resident cell of connective tissue that contains many granules rich in histamine and heparin.Specifically, it is a type of granulocyte derived from the myeloid stem cell that is a part of the immune and neuroimmune systems.

  8. Organic brain syndrome - Wikipedia

    en.wikipedia.org/wiki/Organic_brain_syndrome

    Mastocytosis [15] Meningitis; Psychoorganic syndrome; Stroke/transient ischemic attack (TIA) Withdrawal from drugs, especially sedative hypnotics, e.g. alcohol or benzodiazepines [16] [17] Other conditions that may be related to organic brain syndrome include: clinical depression, neuroses, and psychoses, which may occur simultaneously with the ...

  9. List of antineoplastic agents - Wikipedia

    en.wikipedia.org/wiki/List_of_antineoplastic_agents

    Osteoporosis, including drug- and cancer-related osteoporosis, giant cell tumour of bone and hypercalcaemia of malignancies: Hypercholesterolaemia, cataract, urinary retention, hypocalcaemia, osteonecrosis of the jaw and anaphylaxis. Gemtuzumab ozogamicin: IV: CD33 antibody that induces apoptosis of the tagged cell. Acute myeloid leukaemia