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The Rh blood group system consisted of 49 defined blood group antigens [1] in 2005. As of 2023, there are over 50 antigens among which the five antigens D, C, c, E, and e are among the most prominent. There is no d antigen.
The term "Rh Disease" is commonly used to refer to HDFN due to anti-D antibodies, and prior to the discovery of anti-Rh o (D) immune globulin, it was the most common type of HDFN. The disease ranges from mild to severe, and occurs in the second or subsequent pregnancies of Rh-D negative women when the biologic father is Rh-D positive.
Hemoglobin D (HbD) is a variant of hemoglobin, a protein complex that makes up red blood cells. Based on the locations of the original identification, it has been known by several names such as hemoglobin D-Los Angeles , hemoglobin D-Punjab , [ 1 ] D-North Carolina , D-Portugal , D-Oak Ridge , and D-Chicago. [ 2 ]
Hemoglobin D was discovered in 1951 with one source stating it was the third variant discovered, [2] and another source claiming it was the fourth. [1] Later in 1962, it was found that five other regional variants of hemoglobin D all had the same chemical structure termed hemoglobin D-Punjab.
Blood group Rh(CE) polypeptide is a protein that in humans is encoded by the RHCE gene. [ 5 ] [ 6 ] RHCE has also recently been designated CD240CE ( cluster of differentiation 240CE). The Rh blood group system is the second most clinically significant of the blood groups, second only to ABO.
The study, which involved 106 peri- and postmenopausal women and was presented at the Endocrine Society’s annual meeting in May, indicates women should self-monitor their vasomotor symptoms and ...
Rh blood group, D antigen also known as Rh polypeptide 1 (RhPI) or cluster of differentiation 240D (CD240D) is a protein that in humans is encoded by the RHD gene. [ 5 ] The RHD gene codes for the RhD erythrocyte membrane protein that is the Rh factor antigen of the Rh blood group system . [ 6 ]
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