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Malonic acid is a dicarboxylic acid with structure CH 2 (COOH) 2. The ionized form of malonic acid, as well as its esters and salts , are known as malonates . For example, diethyl malonate is malonic acid's diethyl ester .
Diethyl malonate, also known as DEM, is the diethyl ester of malonic acid. It occurs naturally in grapes and strawberries as a colourless liquid with an apple-like odour, and is used in perfumes. It is also used to synthesize other compounds such as barbiturates, artificial flavourings, vitamin B 1, and vitamin B 6.
A notable method for synthesizing acetamidomalon ester is described in a 1950 patent, [1] which cites a procedure previously featured in Organic Syntheses. [2] The synthesis procedure involves the preparation of malonic acid diethyl ester in acetic acid combined with sodium nitrite (NaNO 2), resulting in diethyl isonitrosomalonate (also known as α-oximinomalonic acid diethyl ester).
Methylmalonic acidemia has an autosomal recessive pattern of inheritance.. Methylmalonic acidemias have an autosomal recessive inheritance pattern, which means the defective gene is located on an autosome, and two copies of the gene—one from each parent—must be inherited to be affected by the disorder.
Methylmalonic acid (MMA) is a chemical compound from the group of dicarboxylic acids. It consists of the basic structure of malonic acid and also carries a methyl group . The salts of methylmalonic acid are called methylmalonates .
Unlike other malonic esters that are derived via malonic ester synthesis, diethyl phenylmalonate is typically indirectly derived via a Claisen condensation with diethyl oxalate and ethyl phenylacetate followed by decarbonylation. [2]
Dimethyl malonate is a diester derivative of malonic acid. It is a common reagent for organic synthesis used, for example, as a precursor for barbituric acid. It is also used in the malonic ester synthesis. It can be synthesized from dimethoxymethane and carbon monoxide. [2]
Disodium malonate is a sodium salt of malonic acid with the chemical formula CH 2 (COONa) 2. It is a white crystal soluble in water but not in alcohols, esters or benzene. It can be prepared from the reaction of sodium hydroxide and malonic acid: CH 2 (COOH) 2 + 2 NaOH → CH 2 (COONa) 2 + 2 H 2 O