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Fluorouracil has been given systemically for anal, breast, colorectal, oesophageal, stomach, pancreatic and skin cancers (especially head and neck cancers). [12] It has also been given topically (on the skin) for actinic keratoses, skin cancers and Bowen's disease [12] (a type of cutaneous squamous-cell carcinoma), and as eye drops for treatment of ocular surface squamous neoplasia. [13]
Urea cream is indicated for debridement and promotion of normal healing of skin areas with hyperkeratosis, particularly where healing is inhibited by local skin infection, skin necrosis, fibrinous or itching debris or eschar. [5] Specific condition with hyperkeratosis where urea cream is useful include: Dry skin and rough skin [5] Dermatitis [5]
Skin damage due to burns, abrasions, wounds and skin diseases also increase absorption. Thus populations with skin damage may be more susceptible to adverse effects of agents that are absorbed through the skin. Certain solvents like dimethyl sulfoxide (DMSO) act as carriers and are frequently used to transport medication through the skin. DMSO ...
Unguentine is an over-the-counter topical antiseptic ointment produced by Lee Pharmaceuticals. It was introduced in 1893 as the first antiseptic surgical dressing ointment by Norwich Pharmaceuticals, who later brought Pepto Bismol to market.
In 1984, Taro acquired Canada-based K-Line Pharmaceuticals. K-Line specialized in generic topical medications for dermatological applications. This niche market then became Taro's primary focus in the North American market. In 2006, Taro was delisted from NASDAQ, after it had to restate financial results downwards for the years 2004, 2005 and ...
If there is a persistent sore that does not heal or a growing lump within the rash, a skin biopsy should be performed to rule out the possibility of skin cancer. If the erythema ab igne lesions demonstrate pre-cancerous changes, the use of 5-fluorouracil cream has been recommended.
Surgery to remove the basal-cell carcinoma affected area and the surrounding skin is thought to be the most effective treatment. [40] A disadvantage with standard surgical excision is a reported higher recurrence rate of basal-cell cancers of the face, [41] especially around the eyelids, [42] nose, and facial structures. [43]
[5] [7] The solvent that is used as a dispersion medium can be aqueous, organic, inorganic, or a system of different solvents. [5] Topical gels are used as a contact or transport medium for active drugs to act on [4] or through the skin. [9] The active drug molecules are entwined into the 3D mesh of the gel and delivered to the site of action.