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A dermatofibroma, or benign fibrous histiocytomas, is a benign nodule in the skin, typically on the legs, elbows or chest of an adult. [3] It is usually painless. [3] It usually ranges from 0.2cm to 2cm in size but larger examples have been reported. [3] It typically results from mild trauma such as an insect bite. [3]
The hard fibroma (fibroma durum) consists of many fibres and few cells, e.g. in skin it is called dermatofibroma (fibroma simplex or nodulus cutaneous). [2] A special form is the keloid, which derives from hyperplastic growth of scars.
These pouches can often be exposed to maternal faeces and urine, a highly different environment to the sterile intrauterine environment seen in eutherian embryos. Despite these differences skin wounds on the marsupial healed without the formation of a scar, proving the irrelevance of the embryonic environment in scar free healing. [citation needed]
After eighty-two days of consecutive injections the defect regenerated to normal tissue. [4] [5] In 2016, scientists could transform a skin cell into any other tissue type via the use of drugs. [6] The technique was noted as safer than genetic reprogramming which, in 2016, was a concern medically. [6]
The white tumor infiltrates the adjacent skeletal muscle (red tissue – lower left) and fat (yellow tissue – upper left). This tendency for invasion of adjacent normal tissues and structures is the reason that desmoid-type fibromatosis has a relatively high rate of local recurrence, even after surgical removal. Specialty: Oncology
The dimple sign or Fitzpatrick's sign is a dermatological sign in which lateral pressure on the skin produces a depression. [ 1 ] [ 2 ] It is associated with dermatofibroma . [ 3 ]
Various studies find that DFSP-FS tumors have higher rates of recurrence after surgical removal than DFSP tumors and may metastasize (i.e. spread to distant tissues). [2] [8] [9] [10] The tumor cells in DFSP and DFSP-FS harbor one or more fusion gene mutations, i.e. mutations that merge two previously independent genes.
Dermatofibrosarcoma protuberans begins as a minor firm area of skin most commonly about to 1 to 5 cm in diameter. It can resemble a bruise, birthmark, or pimple. It is a slow-growing tumor and is usually found on the torso but can occur anywhere on the body. [7] About 90% of DFSPs are low-grade sarcomas.