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Clonidine may also cause bradycardia, theoretically by increasing signaling through the vagus nerve. When given intravenously, clonidine can temporarily increase blood pressure by stimulating α 1 receptors in smooth muscles in blood vessels. [83] This hypertensive effect is not usual when clonidine is given orally or by the transdermal route.
Clonidine and other imidazoline compounds have also been shown to reduce muscle spasms by their central nervous system activity. Tizanidine is perhaps the most thoroughly studied clonidine analog, and is an agonist at α 2-adrenergic receptors, but reduces spasticity at doses that result in significantly less hypotension than clonidine. [26]
Imidazoline receptors are the primary receptors on which clonidine and other imidazolines act. [1] [2] [3] There are three main classes of imidazoline receptor: I 1 is involved in inhibition of the sympathetic nervous system to lower blood pressure, [4] I 2 has as yet uncertain functions but is implicated in several psychiatric conditions, [5] [6] and I 3 regulates insulin secretion.
So, if you’re not staying on top of your water intake, you might find yourself feeling hungry when, really, your body’s in need of a glass of water (or two). Stress. We’ve all been there.
The symptoms can be acute (short-term) or chronic (long-term). They include movement dysfunction such as dystonia (continuous spasms and muscle contractions), akathisia (may manifest as motor restlessness), [ 1 ] parkinsonism characteristic symptoms such as rigidity , bradykinesia (slowness of movement), tremor , and tardive dyskinesia ...
Clonidine is often used to treat tics, specifically Tourettes Disorder, due to research by Dr. Richard Ferre, M.D. of University of Utah. I do not have a link to the specific paper, but you can find it on a Google search "Richard Ferre" Yea, i have Tourettes and i take this. EvilHom3r 18:49, 6 August 2007 (UTC)
Rebound phenomena do not necessarily only occur on discontinuation of a prescribed dosage. Another example is early morning rebound insomnia which may occur when a rapidly eliminated hypnotic wears off which leads to rebounding awakeness forcing the person to become wide awake before he or she has had a full night's sleep.
Sleepiness can also be a response to infection. [4] Such somnolence is one of several sickness behaviors or reactions to infection that some theorize evolved to promote recovery by conserving energy while the body fights the infection using fever and other means.