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Inositol nicotinate, also known as inositol hexanicotinate or inositol hexaniacinate, is a compound of niacin (vitamin B3) and inositol. It is marketed in the United States as a "no-flush" form of niacin in dietary supplements. [1]
Prescription niacin preparations in combination with statin drugs (discontinued) are described above. A combination of niacin and laropiprant had been approved for use in Europe and marketed as Tredaptive. Laropiprant is a prostaglandin D2 binding drug shown to reduce niacin-induced vasodilation and flushing side effects.
Research carried out in 1989 [3] found PGD 2 is the primary mediator of vasodilation (the "niacin flush") after ingestion of niacin (nicotinic acid). A 2012 research paper indicates a causal link between elevated levels of localized PGD 2 and hair growth inhibition. [4]
Taking 325 mg of aspirin 20–30 minutes prior to taking nicotinic acid has also been proven to prevent flushing in 90% of patients, presumably by suppressing prostaglandin synthesis, [4] but this medication also increases the risk of gastrointestinal bleeding, [5] though the increased risk is less than 1 percent.
It claims to flush poisons from the body's fat stores using exercise, saunas, and the consumption of oil and high doses of vitamins, particularly niacin. Medical professionals have judged the method to be unproven, ineffective and/or potentially dangerous.
The body also converts niacin and the amino acid tryptophan into NAD, says Martens — these are both found in some foods and available as supplements, but may not be as effective.
As with niacin and related drugs, the most common adverse effects are flushing (associated with prostaglandin D 2 [2]) and gastrointestinal disturbances such as indigestion, which occur in at least 10% of patients. [1] Flushing can be reduced by taking aspirin 20 to 30 minutes before taking acipimox. Palpitations have also been described.
Example of a label showing the amount of niacin (Vitamin B3), and specifying to be niacinamide in the ingredient section.. The United States Government adopted the terms niacin and niacinamide in 1942 as alternate names for nicotinic acid and nicotinamide, respectively, and encouraged their use in nontechnical contexts to avoid the public’s confusing them with the nearly unrelated (and toxic ...
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