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Activated charcoal, also known as activated carbon, is a medication used to treat poisonings that occurred by mouth. [1] To be effective it must be used within a short time of the poisoning occurring, typically an hour. [1] [2] It does not work for poisonings by cyanide, corrosive agents, iron, lithium, alcohols, or malathion. [2]
However, not all of them are safe to use during pregnancy. One of the components of bismuth subsalicylate is salicylate, which is a component that crosses the placenta. Due to this, there is an increased risk for intrauterine growth retardation, fetal hemorrhage, and maternal hemorrhage within organogenesis and in the second/third trimester. [ 12 ]
The administration of activated charcoal as soon as possible after oral overdose may prevent excessive increase of systemic moxifloxacin exposure. About 3% and 9% of the dose of moxifloxacin, as well as about 2% and 4.5% of its glucuronide metabolite are removed by continuous ambulatory peritoneal dialysis and hemodialysis, respectively."
[5] [2] In small children one or two pills can be fatal. [6] An electrocardiogram (ECG) should be included in the assessment when there is concern of an overdose. [2] In overdose activated charcoal is often recommended. [1] People should not be forced to vomit. [2] In those who have a wide QRS complex (> 100 ms) sodium bicarbonate is ...
[63] [62] Administering activated charcoal later than 2 hours can be considered in patients that may have delayed gastric emptying due to co-ingested drugs or following ingestion of sustained- or delayed-release paracetamol preparations. Activated charcoal should also be administered if co-ingested drugs warrant decontamination. [42]
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In very large overdoses, multi-dose activated charcoal is a mainstay of treatment as the drug undergoes enterohepatic recirculation. Urine alkalization (achieved with sodium bicarbonate) enhances renal excretion. Hemodialysis is effective in removing phenobarbital from the body and may reduce its half-life by up to 90%. [40]
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