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A review that considered berberine’s effects on heart health found some studies supporting this claim, but due to the high risk of bias, the researchers recommended more clinical trials be ...
Berberine is known to inhibit the activity of CYP3A4, an important enzyme involved in drug metabolism and clearance of endogenous substances, including steroid hormones such as cortisol, progesterone and testosterone.
A systematic review and meta-analysis of 49 studies, published in Frontiers in Nutrition in 2022, found that "although (berberine) may affect weight, it does not have a statistically significant ...
Is berberine really “nature’s Ozempic,” as social media influencers claim? No way, experts say, and the plant-based compound may be dangerous to some. Forget TikTok claims: ‘Nature’s ...
Many people are taking berberine supplements for high cholesterol, diabetes, PCOS, and weight loss. Here's what experts have to say about 'nature's Ozempic.'
The alkaloid berberine upregulates HNF4A expression. [11] This gene plays a pivotal role in the expression and synthesis of SHBG, an important glycoprotein made primarily in the liver, [12] which in addition to lowering insulin-resistance also reduces levels of free Estrogen as-well as prolonging the half-life of testosterone. [citation needed]
There are two variants of the estrogen receptor, alpha and beta and many phytoestrogens display somewhat higher affinity for ER-β compared to ER-α. [14] The key structural elements that enable phytoestrogens to bind with high affinity to estrogen receptors and display estradiol-like effects are: [2]
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