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Unlike undersized cats of normal proportions (such as Toy and Teacup Persians), [6] dwarf cats suffer from a genetic mutation called pseudoachondroplasia (dwarfism without enlarged heads), a type of osteochondrodysplasia (bone and cartilage disorder). These genetic disorders of bone and cartilage are typically manifested as abnormal bone shape ...
The impact of KRAS mutations is heavily dependent on the order of mutations. Primary KRAS mutations generally lead to a self-limiting hyperplastic or borderline lesion, but if they occur after a previous APC mutation it often progresses to cancer. [18] KRAS mutations are more commonly observed in cecal cancers than colorectal cancers located in ...
RALD is caused by gain-of-function somatic mutations in the genes NRAS or KRAS. NRAS and KRAS are members of the RAS subfamily and are implicated in many types of cancer. [5] Somatic mutations are changes in DNA that occur after conception. Although generally somatic mutations can develop in any cell of the body, in RALD the somatic mutations ...
Mutations in this gene also cause white spotting. [9] Since a large variety of coat patterns exist within the various cat breeds, the cat is an excellent animal to study the coat genetics of hair growth and coloration. [10] Several genes interact to produce cats' hair color and coat patterns.
The following is a list of genetic disorders and if known, type of mutation and for the chromosome involved. Although the parlance "disease-causing gene" is common, it is the occurrence of an abnormality in the parents that causes the impairment to develop within the child.
Somatic mutations in the Ras/MAPK pathway can cause cancers and disorders such as RAS-associated autoimmune leukoproliferative disorder (RALD) or juvenile myelomonocytic leukemia (JMML). These syndromes may share some features with RASopathies but are not considered true RASopathies if caused by somatic mutation. [ 3 ]
The most common mutations are found at residue G12 in the P-loop and the catalytic residue Q61. The glycine to valine mutation at residue 12 renders the GTPase domain of Ras insensitive to inactivation by GAP and thus stuck in the "on state". Ras requires a GAP for inactivation as it is a relatively poor catalyst on its own, as opposed to other ...
Skin disorders are among the most common health problems in cats and have many causes. The condition of a cat's skin and coat can be an important indicator of its general health. Cheyletiellosis is a mild dermatitis caused by mites of the genus Cheyletiella. It is also known as walking dandruff due to skin scales being carried by the mites ...