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  2. Drug of last resort - Wikipedia

    en.wikipedia.org/wiki/Drug_of_last_resort

    A drug of last resort (DoLR), also known as a heroic dose, [1] is a pharmaceutical drug which is tried after all other drug options have failed to produce an adequate response in the patient. Drug resistance , such as antimicrobial resistance or antineoplastic resistance , may make the first-line drug ineffective, especially in case of ...

  3. Vancomycin - Wikipedia

    en.wikipedia.org/wiki/Vancomycin

    Vancomycin is a glycopeptide antibiotic medication used to treat certain bacterial infections. [7] It is administered intravenously (injection into a vein) to treat complicated skin infections, bloodstream infections, endocarditis, bone and joint infections, and meningitis caused by methicillin-resistant Staphylococcus aureus. [8]

  4. Clostridioides difficile infection - Wikipedia

    en.wikipedia.org/wiki/Clostridioides_difficile...

    For the first episode of recurrent C. difficile infection, the 2017 IDSA guidelines recommend oral vancomycin at a dose of 125 mg four times daily for 10 days if metronidazole was used for the initial episode. If oral vancomycin was used for the initial episode, then a prolonged oral vancomycin pulse dose of 125 mg four times daily for 10–14 ...

  5. Fecal microbiota transplant - Wikipedia

    en.wikipedia.org/wiki/Fecal_microbiota_transplant

    It has been recommended that endoscopic FMT be elevated to first-line treatment for people with deterioration and severe relapsing C. difficile infection. [8] In November 2022, faecal microbiota transplant (Biomictra) was approved for medical use in Australia, [1] [18] and fecal microbiota, live (Rebyota) was approved for medical use in the ...

  6. Clostridioides difficile - Wikipedia

    en.wikipedia.org/wiki/Clostridioides_difficile

    Clostridioides difficile (syn. Clostridium difficile) is a bacterium known for causing serious diarrheal infections, and may also cause colon cancer. [4] [5] It is known also as C. difficile, or C. diff (/ s iː d ɪ f /), and is a Gram-positive species of spore-forming bacteria. [6]

  7. Glycopeptide antibiotic - Wikipedia

    en.wikipedia.org/wiki/Glycopeptide_antibiotic

    Glycopeptide antibiotics are a class of drugs of microbial origin that are composed of glycosylated cyclic or polycyclic nonribosomal peptides.Significant glycopeptide antibiotics include the anti-infective antibiotics vancomycin, teicoplanin, telavancin, ramoplanin, avoparcin and decaplanin, corbomycin, complestatin and the antitumor antibiotic bleomycin.

  8. Metronidazole - Wikipedia

    en.wikipedia.org/wiki/Metronidazole

    It is an option for a first episode of mild-to-moderate Clostridioides difficile colitis if vancomycin or fidaxomicin is unavailable. [ 10 ] [ 11 ] Metronidazole is available orally (by mouth), as a cream or gel, and by slow intravenous infusion (injection into a vein).

  9. Trimethoprim/sulfamethoxazole - Wikipedia

    en.wikipedia.org/wiki/Trimethoprim/sulfamethoxazole

    Co-trimoxazole is the recommended standard treatment for whipple's disease in some treatment protocols. [54] [55] [56] Fungal and protozoal infections: Isosporiasis: No: No: No: Clinical trials have confirmed its use in this indication. [57] Malaria: No: No: No: Clinical trials have confirmed its efficacy in both the treatment and prevention of ...

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