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  2. Interleukin 11 - Wikipedia

    en.wikipedia.org/wiki/Interleukin_11

    [8] [9] It was developed as a recombinant protein (rhIL-11) as the drug substance oprelvekin. The human IL-11 gene, consisting of 5 exons and 4 introns, is located on chromosome 19, [6] and encodes a 23 kDa protein. IL-11 is a member of the IL-6-type cytokine family, distinguished based on their use of the common co-receptor gp130.

  3. Exagamglogene autotemcel - Wikipedia

    en.wikipedia.org/wiki/Exagamglogene_autotemcel

    Exagamglogene autotemcel is the first cell-based gene therapy treatment utilizing CRISPR/Cas9 gene editing technology to be approved by the US Food and Drug Administration (FDA). [13] The most common side effects include low levels of platelets and white blood cells, mouth sores, nausea, musculoskeletal pain, abdominal pain, vomiting, febrile ...

  4. Oprelvekin - Wikipedia

    en.wikipedia.org/wiki/Oprelvekin

    Oprelvekin is recombinant interleukin eleven (IL-11), [1] a thrombopoietic growth factor that directly stimulates the proliferation of hematopoietic stem cells and megakaryocyte progenitor cells and induces megakaryocyte maturation resulting in increased platelet production.

  5. Interleukin 11 receptor alpha subunit - Wikipedia

    en.wikipedia.org/wiki/Interleukin_11_receptor...

    Interleukin 11 receptor, alpha subunit is a subunit of the interleukin 11 receptor. IL11RA is its human gene. [5] Interleukin 11 is a stromal cell-derived cytokine that belongs to a family of pleiotropic and redundant cytokines that use the gp130 transducing subunit in their high affinity receptors. This gene encodes the IL-11 receptor, which ...

  6. Teen boy first in Michigan to get gene editing treatment for ...

    www.aol.com/teen-boy-first-michigan-gene...

    Its physicians also plan before the end of the year to use a newly approved gene-editing therapy to, for the first time, treat a Michigan person with sickle cell disease using another Lyfgenia or ...

  7. Off-target genome editing - Wikipedia

    en.wikipedia.org/wiki/Off-target_genome_editing

    In order for gene editing technologies to make the leap towards safe and widespread use in the clinic, the rate of off-target modification needs to be rendered obsolete. The safety of gene therapy treatment is of utmost concern, especially during clinical trials when off-target modifications can block the further development of a candidate ...

  8. Anakinra - Wikipedia

    en.wikipedia.org/wiki/Anakinra

    More than ten percent of people taking Anakinra have injection site reactions, headaches, and have increased cholesterol levels. [1] Recipients have eight percent more patients decrease white blood cells counts, two percent more patients decrease platelets counts, one percent more patients get severe infections (4.5% for patients with asthma compared to 0% placebo patients with asthma). [1]

  9. Gene therapy for osteoarthritis - Wikipedia

    en.wikipedia.org/wiki/Gene_therapy_for...

    When administered systemically, or in high doses, viral vectors may induce an inflammatory response, which can cause minor side effects such as edema or serious ones like multisystem organ failure. [30] It may also be difficult to administer gene therapy repeatedly due to the immune system's enhanced response to viruses.