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Tricyclic antidepressants (TCAs) are a class of medications that are used primarily as antidepressants. TCAs were discovered in the early 1950s and were marketed later in the decade. [ 1 ] They are named after their chemical structure , which contains three rings of atoms .
Metapramine (brand names Prodastene, Timaxel) is a tricyclic antidepressant (TCA) developed by Rhone Poulenc [1] that was introduced for the treatment of depression in France in 1984. [2] [3] In addition to its efficacy against affective disorders, it also has analgesic properties, [4] [5] and may be useful in the treatment of pain.
Elimination half-life: 6–11 hours [3] Excretion: Urine ... Since no antidote for tricyclic antidepressant overdose is known, ... Toggle the table of contents.
Medications for Depression: An Overview. Antidepressants are a class of medications used very commonly to treat depression. In fact, nearly 13 percent of people 12 and over in the U.S. used ...
Depression enters some people’s lives in waves depending on life circumstances. ... Tricyclic antidepressants (or TCAs) are a type of antidepressant developed in the 20th century.
Nortriptyline is a tricyclic compound, specifically a dibenzocycloheptadiene, and possesses three rings fused together with a side chain attached in its chemical structure. [43] Other dibenzocycloheptadiene tricyclic antidepressants include amitriptyline (N-methylnortriptyline), protriptyline, and butriptyline.
Tricyclic antidepressants (TCAs). Tricyclic antidepressants are older antidepressants that, due to their side effect profiles, typically aren’t prescribed as first-line depression treatments today.
Desipramine, sold under the brand name Norpramin among others, is a tricyclic antidepressant (TCA) used in the treatment of depression. [8] It acts as a relatively selective norepinephrine reuptake inhibitor, though it does also have other activities such as weak serotonin reuptake inhibitory, α 1-blocking, antihistamine, and anticholinergic effects.