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Midazolam is known to cause respiratory depression. In healthy humans, 0.15 mg/kg of midazolam may cause respiratory depression, which is postulated to be a central nervous system (CNS) effect. [48] When midazolam is administered in combination with fentanyl, the incidence of hypoxemia or apnea becomes more likely. [49]
Midazolam is the most commonly prescribed for this use because of its strong sedative actions and fast recovery time, as well as its water solubility, which reduces pain upon injection. Diazepam and lorazepam are sometimes used. Lorazepam has particularly marked amnesic properties that may make it more effective when amnesia is the desired effect.
The tables below contain a sample list of benzodiazepines and benzodiazepine analogs that are commonly prescribed, with their basic pharmacological characteristics, such as half-life and equivalent doses to other benzodiazepines, also listed, along with their trade names and primary uses.
Psychonauts is a 2005 platform game developed by Double Fine Productions and published by Majesco Entertainment for Microsoft Windows, Xbox and PlayStation 2.. Set in a retro-futuristic version of the 1980s, Psychonauts follows Razputin (Raz), a young boy gifted with psychic abilities, who runs away from a circus to try to sneak into a summer camp for those with similar powers to become a ...
A futuristic healing machine capable of piercing into one's memories is Maxime's only hope to save her dying girlfriend. Along with the help of her mother Samantha (Fiona Dourif), the only person she knows that can operate the machine, Max must traverse into the dark recesses of her lover's mind in order to locate the "essential memory" that could save her life, all the while being hunted by a ...
In a study in rats, cross-tolerance between the benzodiazepine drug chlordiazepoxide and bretazenil has been demonstrated. [11] In a primate study bretazenil was found to be able to replace the full agonist diazepam in diazepam dependent primates without precipitating withdrawal effects, demonstrating cross tolerance between bretazenil and benzodiazepine agonists, whereas other partial ...
Psychonauts 2 is a 2021 platform game developed by Double Fine and published by Xbox Game Studios.The game was announced at The Game Awards 2015 ceremony, and released on August 25, 2021 for PlayStation 4, Windows, Xbox One and Xbox Series X/S, and on May 24, 2022 for Linux and macOS.
Using his Clairvoyance ability, Raz discovers Truman is being held at an abandoned Psychonaut research facility in an oceanic region known as the Rhombus of Ruin (a play on the Bermuda Triangle), built to study a large underwater deposit of Psilirium (a fictional element variant of Psitanium that can distort psychic powers and creates illusions ...