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Letrozole, sold under the brand name Femara among others, is an aromatase inhibitor medication that is used in the treatment of breast cancer for post-menopausal women. [ 1 ] It was patented in 1986 and approved for medical use in 1996. [ 4 ]
The medication has been found to achieve 96.7% to 97.3% inhibition of aromatase at a dosage of 1 mg/day and 98.1% inhibition of aromatase at a dosage of 10 mg/day in humans. [ 3 ] [ 2 ] As such, 1 mg/day is considered to be the minimal dosage required to achieve maximal suppression of aromatase with anastrozole. [ 3 ]
[11] [7] Peak levels of tamoxifen after a single 40 mg oral dose were 65 ng/mL and steady state levels at 20 mg/day were 310 ng/mL. [5] Levels of tamoxifen show clear dose dependency across a dosage range of 1 to 20 mg/day. [5] [93] Endoxifen levels are approximately 5 to 10 times higher than afimoxifene levels, with large interindividual ...
50–250 mg 1×/2–4 weeks Testosterone undecanoate: Aveed, Nebido: Oil solution: 750–1,000 mg 1×/10–14 weeks Testosterone buciclate a – Aqueous suspension: 600–1,000 mg 1×/12–20 weeks Implant: Testosterone: Testopel: Pellet: 150–1,200 mg/3–6 months Notes: Men produce about 3 to 11 mg of testosterone per day (mean 7 mg/day in ...
Lisinopril is a medication belonging to the drug class of angiotensin-converting enzyme (ACE) inhibitors and is used to treat hypertension (high blood pressure), heart failure, and heart attacks. [7]
2005 (January): The product insert added a warning in bold-face type: "Do not use in cats." [56] 2005: The FDA sent a Notice of Violation to the manufacturer for its promotional materials which included promotion of the drug for off-label use. [57] 2020 (February): A meloxicam injection was approved for use in the United States.
Midazolam 1 & 5 mg/mL injections (Canada). Benzodiazepines possess psycholeptic, sedative, hypnotic, anxiolytic, anticonvulsant, muscle relaxant, and amnesic actions, [4] [5] which are useful in a variety of indications such as alcohol dependence, seizures, anxiety disorders, panic, agitation, and insomnia.
January 10–15 – A national plebiscite referendum is held among the citizens' assemblies to ratify the new Constitution. [1] [2]January 15 – Chinese Lim Seng (Guan Suo So), upon order from Pres. Marcos on January 3, is publicly executed by firing squad in a firing range in Fort Bonifacio, Rizal for drug trafficking; the country's first execution by that method after 27 years, and only ...