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Doctors have raised concerns about the safety of taking turmeric and black pepper supplements after discovering a small group of patients have experienced liver injury. ... the correct dose is the ...
Purified extracts of the sweet chili pepper containing capsinoids have been extensively studied through rigorous safety tests, including evaluation of chronic toxicity, reproduction, genotoxicity, and teratology in animals, single oral administration and pharmacokinetics in humans.
Beyond adverse effects from the herb itself, "adulteration, inappropriate formulation, or lack of understanding of plant and drug interactions have led to adverse reactions that are sometimes life threatening or lethal." [3]
It is 3 to 4 orders of magnitude more potent than capsaicin for effects on thermoregulation and neurogenic inflammation. [14] For rats, LD50 through oral ingestion is 148.1 mg/kg. [ 15 ] It causes severe burning pain in sub-microgram (less than 1/1,000,000th of a gram) quantities when ingested orally.
Common side effects include vomiting, black stools, diarrhea, and constipation. [1] A more serious side effect, pneumonitis, may result if aspirated into the lungs. [1] [2] Gastrointestinal obstruction and ileus are less common but serious adverse effects. [1] Use in pregnancy and breastfeeding is generally safe. [3]
The amount of piperine varies from 1–2% in long pepper, to 5–10% in commercial white and black peppers. [6] [7] Piperine can also be prepared by treating the solvent-free residue from a concentrated alcoholic extract of black pepper with a solution of potassium hydroxide to remove resin (said to contain chavicine, an isomer of piperine). [7]
Short-term use of ginseng (under 3 months) is unlikely to produce side effects and appears safe for most people. Side effects, often associated with longer term use, can include headaches, insomnia, and gastrointestinal problems. There are many conditions in which ginseng use has special precautions and warnings.
Side effects from vitamin overdoses may occur, especially in patients with kidney failure. In very large doses, vitamin C in kidney-failure patients can cause severe side effects such as oxalate deposits in bone and soft tissues and may interfere with the absorption and metabolism of vitamin B 12. The product contains 1 g of vitamin C per ...
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