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Adderall and Mydayis [11] are trade names [note 2] for a combination drug containing four salts of amphetamine.The mixture is composed of equal parts racemic amphetamine and dextroamphetamine, which produces a (3:1) ratio between dextroamphetamine and levoamphetamine, the two enantiomers of amphetamine. [13]
It was previously marketed by itself under the brand name Cydril, but is now available only in combination with dextroamphetamine in varying ratios under brand names like Adderall and Evekeo. [ 10 ] [ 5 ] The drug is known to increase wakefulness and concentration in association with decreased appetite and fatigue .
Initially the drug was used to treat narcolepsy, chronic fatigue, depression, and to counter the sedating effects of other medications. The drug began to be used for ADHD in the 1960s and steadily rose in use. [223] In 1975, pemoline (Cylert) was approved by the U.S. FDA for use in the treatment of ADHD. While an effective agent for managing ...
Typically, the recommended starting dosage for Wellbutrin is 200mg per day, with a maximum dosage of 450mg per day. The starting dosage is taken as 100mg twice per day.
Amphetamine is a weak base with a pK a of 9.9; [3] consequently, when the pH is basic, more of the drug is in its lipid soluble free base form, and more is absorbed through the lipid-rich cell membranes of the gut epithelium. [3] [29] Conversely, an acidic pH means the drug is predominantly in a water-soluble cationic (salt) form, and less is ...
In October, the FDA announced a shortage of the immediate-release form of amphetamine mixed salts, which includes the brand-name drug Adderall. These are stimulants used to treat ADHD as well as ...
In October 2022, the U.S. Food and Drug Administration announced a shortage of the immediate-release formula of Adderall due to a manufacturer delay. A year later, the shortage persists and now ...
Amphetamine is a weak base with a pK a of 9.9; [20] consequently, when the pH is basic, more of the drug is in its lipid soluble free base form, and more is absorbed through the lipid-rich cell membranes of the gut epithelium. [20] [87] Conversely, an acidic pH means the drug is predominantly in a water-soluble cationic (salt) form, and less is ...
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