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In parallel to albuminuria in 1936, discussion on renal lesions observed in patients with diabetes led to the description, by Kimmelstiel and Wilson, of the characteristic nodular fibrotic observed in the diabetic glomeruli (Kimmelstiel and Wilson, 1936b). Kimmelstiel and Wilson introduced the term diabetic nephropathy (DN) to define a clinical ...
Other symptoms include tiredness, headaches, a general feeling of illness, nausea, vomiting, frequent daytime urination, lack of appetite, itchy skin, and leg swelling. [2] The clinical presentation of diabetic nephropathy (DN) is characterized by proteinuria (protein in the urine), hypertension and progressive loss of kidney function.
Bizarre parosteal osteochondromatous proliferation (BPOP), also known as Nora's lesion, [4] is a type of non-cancerous bone tumor belonging to the group of cartilage tumors. [ 1 ] [ 2 ] [ 5 ] It is generally seen in the tubular bones of the hands and feet , [ 6 ] where it presents with a rapidly enlarging painless lump in a finger or toe.
Wilson's disease (also called hepatolenticular degeneration) is a genetic disorder characterized by the excess build-up of copper in the body. Symptoms are typically related to the brain and liver. Liver-related symptoms include vomiting, weakness, fluid build-up in the abdomen, swelling of the legs, yellowish skin, and itchiness.
Keratolysis exfoliativa (also known as"lamellar dyshidrosis", [1] "recurrent focal palmar peeling", [2] "recurrent palmar peeling" [1]: 212 [2]) is a sometimes harmless, sometimes painful skin condition that can affect the focal surface of the fingers and/or the palm or soles of the feet.
Complicated comorbidity: It is the result of the primary disease and often subsequent after sometime after its destabilization appears in the shape of target lesions (for example chronic nephratony resulting from diabetic nephropathy (Kimmelstiel-Wilson disease) in patients with type 2 diabetes; development of brain infarction resulting from ...
Paresthesias of the hands, feet, legs, and arms are common transient symptoms. The briefest electric shock type of paresthesia can be caused by tweaking the ulnar nerve near the elbow; this phenomenon is colloquially known as bumping one's "funny bone". Similar brief shocks can be experienced when any other nerve is tweaked (e.g. a pinched neck ...
Diagnosis is based on symptoms, supported by a skin biopsy or blood tests. [6] While no cure is known, treatment may improve symptoms. [2] Medications used include corticosteroids, methotrexate, and non-steroidal anti-inflammatory drugs (NSAIDs). [2] Outcome depends on the extent of disease. [3]