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Medications are used to reverse the symptoms of extrapyramidal side effects caused by antipsychotics or other drugs, by either directly or indirectly increasing dopaminergic neurotransmission. The treatment varies by the type of the EPS, but may involve anticholinergic agents such as procyclidine, benztropine, diphenhydramine, and trihexyphenidyl.
Aside from reduced extrapyramidal symptoms, and with the clear exception of clozapine, it is unclear whether the atypical (second-generation) antipsychotics offer advantages over older, first generation antipsychotics. [3] [27] [89] Amisulpride, olanzapine, risperidone and clozapine may be more effective but are associated with greater side ...
Cariprazine. Cariprazine, sold under the brand name Vraylar among others, is an atypical antipsychotic developed by Gedeon Richter, [8] which is used in the treatment of schizophrenia, bipolar mania, [9] bipolar depression, [10] and major depressive disorder. [6]
Asenapine. Asenapine, sold under the brand name Saphris among others, is an atypical antipsychotic medication used to treat schizophrenia and acute mania associated with bipolar disorder as well as the medium to long-term management of bipolar disorder. [4][10]
The atypical antipsychotics (AAP), also known as second generation antipsychotics (SGAs) and serotonin–dopamine antagonists (SDAs), [1] [2] are a group of antipsychotic drugs (antipsychotic drugs in general are also known as tranquilizers and neuroleptics, although the latter is usually reserved for the typical antipsychotics) largely introduced after the 1970s and used to treat psychiatric ...
Pimavanserin. Pimavanserin, sold under the brand name Nuplazid, is an atypical antipsychotic which is approved for the treatment of Parkinson's disease psychosis. [ 3 ] Unlike other antipsychotics, pimavanserin is not a dopamine receptor antagonist, [ 4 ] but rather is a selective inverse agonist of the serotonin 5-HT 2A receptor.
Key:QZUDBNBUXVUHMW-UHFFFAOYSA-N Y. (verify) Clozapine, sold under the brand name Clozaril among others, is a psychiatric medication and was the first atypical antipsychotic (also called second-generation antipsychotic) to be discovered. [6] It is primarily used to treat people with schizophrenia and schizoaffective disorder who have had an ...
[15] [1] These drugs have fewer extrapyramidal side effects and are less likely to affect prolactin levels when compared to typical antipsychotics. [11] Amisulpride binds D 2 and D 3 [2] and is used as an antipsychotic, antidepressant and also treats bipolar disorder. [1] It treats both the positive and negative symptoms of schizophrenia. [13]