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Dynabeads were developed after John Ugelstad managed to create uniform polystyrene spherical beads (defined as microbeads) of exactly the same size, [1] [2] at the University of Trondheim, Norway in 1976, something otherwise only achieved by NASA [3] in the weightless conditions of SkyLab. Dynabeads are typically 1 to 5 micrometers in diameter.
Superparamagnetic microbeads: the monosized Dynabeads (scanning electron microscope image)Microbeads, also called Ugelstad particles [1] [2] [3] after the Norwegian chemist, professor John Ugelstad, who invented them in 1977 and patented the method in 1978, [4] are uniform polymer particles, typically 0.5 to 500 microns in diameter.
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Ugelstad was born in Trondheim to Karen Stene (1898-1993) and Petter Endresen Ugelstad (1893-1975), a factory owner. He grew up and attended school in Trondheim. After graduating in 1941 he began to study chemistry at Norwegian Institute of Technology (NTH); the German occupation of Trondheim during World War II delayed his studies and he passed the engineering exam in 1948.
Each bead is made of thin-walled, air-filled bubbles of polystyrene. Expanded polystyrene (EPS) is a rigid and tough, closed-cell foam with a normal density range of 11 to 32 kg/m 3. [47] It is usually white and made of pre-expanded polystyrene beads. The manufacturing process for EPS conventionally begins with the creation of small polystyrene ...
Antibodies coating paramagnetic beads will bind to antigens present on the surface of cells thus capturing the cells and facilitate the concentration of these bead-attached cells. The concentration process is created by a magnet placed on the side of the test tube bringing the beads to it. MACS systems (Magnetic Cell Separation system): [6] [3]
While some people dread gift shopping, I thrive when it comes time to shop for the different people on my list. I love Christmas gift shopping, whether I’m trying to find a gift for my mother-in ...
The beads in SPA are formed from the incorporation of scintillant into small beads known as fluomicrospheres. These are specially designed to bind with specific molecules. When the bead is in close proximity to the radioactive molecule, light is stimulated. The photonmultiplier tube (PMT) can be used to detect the emitted photons.
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