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The WHO classification of tumours of the central nervous system is a World Health Organization Blue Book that defines, describes and classifies tumours of the central nervous system (CNS). Currently, as of 2023, clinicians are using the 5th edition, which incorporates recent advances in molecular pathology. [ 1 ]
Most brain tumors have higher ADC than normal brain tissues and doctors can match the observed ADC of the patient's brain tumor with a list of accepted ADC to identify tumor type. DWI is also useful for treatment and therapy purposes where changes in diffusion can be analyzed in response to drug, radiation, or gene therapy.
The concept of grading of the tumors of the central nervous system, agreeing for such the regulation of the "progressiveness" of these neoplasias (from benign and localized tumors to malignant and infiltrating tumors), dates back to 1926 and was introduced by P. Bailey and H. Cushing, [1] in the elaboration of what turned out the first systematic classification of gliomas.
The current (5th) edition of the WHO Classification of Tumors of the Central Nervous System classifies embryonal tumor of the central nervous system into six subtypes: medulloblastoma, cribiform neuroepithelial tumor, embryonal tumor with multilayered rosettes, CNS neuroblastoma, FOXR2-activated, CNS tumor with BCOR internal tandem duplication, and CNS embryonal tumor. [1]
The WHO Classification of Tumours, more commonly known as the WHO Blue Books, is a series of books that classify tumours.They are compiled by expert consensus and published by the World Health Organization's (WHO) International Agency for Research on Cancer (IARC).
The 2007 WHO Classification of Tumors of the Central Nervous System [37] was the last classification mainly based on microscopy features. The new 2016 WHO Classification of Tumors of the Central Nervous System [38] was a paradigm shift: some of the tumors were defined also by their genetic composition as well as their cell morphology.
A central nervous system tumor (CNS tumor) is an abnormal growth of cells from the tissues of the brain or spinal cord. [1] CNS tumor is a generic term encompassing over 120 distinct tumor types. [ 2 ]
Diffuse hemispheric glioma, H3G34 mutant (DHG) is a rare, high-grade, infiltrative WHO grade 4 brain tumor most often found in adolescents and young adults. [1] [2] The majority are found in the frontal, parietal, and temporal lobes. [3]
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