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Meclizine is effective in inhibiting nausea, vomiting, and dizziness caused by motion sickness. [10] The drug is safe for treating nausea in pregnancy and is a first-line therapy for this use. [11] [12] Meclizine may not be strong enough for especially sickening motion stimuli, and second-line defenses should be tried in those cases. [13]
However, the mean terminal half-life elimination for young volunteer subjects administered 75 mg cinnarizine, was found to be 23.6 ± 3.2 hours. [ 2 ] A study that administered 75 mg doses of cinnarizine, twice a day for twelve days, to healthy volunteers, observed that cinnarizine did accumulate in the body, with a steady-state accumulation ...
For the drugs administered by oral and dermal route, the units of threshold dose are mg/kg body-weight/day (dose of the drug in mg per body weight in kg per day) or ppm (parts per million), while the threshold dose of drugs by inhalation delivery has the unit of mg/L 6h/day (amount of drug in mg in 1L of air, for 6 hours per day). [8]
Acceptable daily intake or ADI is a measure of the amount of a specific substance (originally applied for a food additive, later also for a residue of a veterinary drug or pesticide) in food or drinking water that can be ingested (orally) daily over a lifetime without an appreciable health risk. [1]
There’s a maximum daily dose, so it’s possible to take too much metformin. Metformin overdose can include the following symptoms: Abnormally fast or slow heartbeat
The DDD of combination tablets (containing more than one drug) is more complex, most taking into account a "unit dose", though combination tablets used for high blood pressure take the number of doses per day into account. [1] The formula for determining the dose is: [1]
The drug is "Meclizine," not "Meclozine." At least in English-speaking countries...for which this article is intended. — Preceding unsigned comment added by 67.79.29.210 18:45, 18 October 2012 (UTC) Per WP:MOSMED#Drugs, medications and devices, we are using International Nonproprietary Names; in this case "meclozine". The alternative name is ...
A reference dose is the United States Environmental Protection Agency's maximum acceptable oral dose of a toxic substance, "below which no adverse noncancer health effects should result from a lifetime of exposure". Reference doses have been most commonly determined for pesticides. The EPA defines an oral reference dose (abbreviated RfD) as: