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Paracetamol's bioavailability is dose-dependent: it increases from 63 % for 500 mg dose to 89 % for 1000 mg dose. [6] Its plasma terminal elimination half-life is 1.9–2.5 hours, [ 6 ] and volume of distribution is roughly 50 L. [ 132 ] Protein binding is negligible, except under the conditions of overdose, when it may reach 15–21 %. [ 6 ]
Some medicine is in short supply. We talked to the pharmacy manager of the UNC Health Carolina Care Pharmacy Network to get answers.
Opioids, such as morphine, is an example of a drug of choice for moderate-severe pain in children with medical illnesses. [36] Some side effects of opioid use can include cognition deficits, dependence, altered mood, and disturbances of endocrine development.
An equianalgesic chart can be a useful tool, but the user must take care to correct for all relevant variables such as route of administration, cross tolerance, half-life and the bioavailability of a drug. [5] For example, the narcotic levorphanol is 4–8 times stronger than morphine, but also has a much longer half-life. Simply switching the ...
An inspection report by the U.S. Food and Drug Administration has revealed disturbing details about the McNeil Consumer Healthcare manufacturing plant that produced liquid versions of infant and ...
Amid surges of RSV, flu and COVID-19, some parents are having a tough time finding children's medications like Tylenol and Motrin. Experts share tips to help.
The 2010 Johnson & Johnson children's product recall involved 43 over-the-counter children's medicines announced by McNeil Consumer Healthcare, a subsidiary of Johnson & Johnson, on April 30, 2010. Medications in the recall included liquid versions of Tylenol, Tylenol Plus, Motrin, Zyrtec, and Benadryl. The products were recalled after it was ...
On April 30, 2010, another recall was issued for 40 products including liquid infant and children's pain relievers Tylenol and Motrin, and allergy medications Zyrtec and Benadryl. [19] An FDA report said its inspectors found thick dust and grime covering certain equipment, a hole in the ceiling, and duct tape-covered pipes at the Fort ...
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