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Ibuprofen, an analgesic and non-steroidal anti-inflammatory drug (NSAID), [1] is sold under many brand-names around the world. The most common are Brufen (its earliest registered trademark), Advil, Motrin, and Nurofen .
Calpol also comes in a form containing ibuprofen, marketed under the name Calprofen. Calpol Night, a product containing paracetamol and an antihistamine, was listed for use from 2+ months. However, this was changed and it is now only considered suitable for children over the age of 6 years. [4]
Ibuprofen was derived from propionic acid by the research arm of Boots Group during the 1960s. [73] The name is derived from the 3 functional groups: isobutyl (ibu) propionic acid (pro) phenyl (fen). [74] Its discovery was the result of research during the 1950s and 1960s to find a safer alternative to aspirin.
An alternative industrial synthesis developed at Celanese involves firstly direct acylation of phenol with acetic anhydride in the presence of hydrogen fluoride to a ketone, then the conversion of the ketone with hydroxylamine to a ketoxime, and finally the acid-catalyzed Beckmann rearrangement of the cetoxime to the para-acetylaminophenol product.
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